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br Steroidogenesis in the skin The synthesis of
2022-11-18
Steroidogenesis in the skin The synthesis of steroid hormones takes place in many tissues of which the adrenal glands, ovaries, testis, placenta and beta adrenergic blockers are considered to be classical steroidogenic organs. Nevertheless, skin constitutes an important peripheral steroidogenic
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The importance of TARPs for AMPAR expression and function wa
2022-11-18
The importance of TARPs for AMPAR expression and function was revealed initially in the cerebellum, where the lack of γ-2 in the mutant mice waggler and stargazer (stg/stg) was associated with a selective loss of AMPAR-mediated synaptic currents in cerebellar granule phosphatidylinositol 4-kinase (
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The reactions and the control mechanisms described
2022-11-18
The reactions and the control mechanisms described are all supported by observations. For example the reactions require that different compounds are formed in different groups of Riociguat cells and this has been observed [15]. Intravenous injection of glycine results in reduced utilisation of gluc
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Circulating adrenal derived stress hormones
2022-11-18
Circulating adrenal-derived stress hormones, epinephrine and corticosterone mediate their tissue effects through adrenergic (AR; α and β) and glucocorticoid (GR) receptors. AR are widely distributed throughout the body and although epinephrine is a prototypical agonist for all types of AR, the selec
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Our findings establish a critical link between HemAC Lm dime
2022-11-18
Our findings establish a critical link between HemAC-Lm dimeric structure and cAMP synthesis that helps in explaining how globin-A domain influences AC domain. The following possible homodimeric structure of wild type full length HemAC-Lm has been proposed to explain the role of this globin-A domain
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Finally one can ask whether
2022-11-18
Finally, one can ask whether these results throw any light on the nature of the target in SNMG patients. Interestingly, the results of the in vitro incubations suggested that SNMG sera might increase AChR expression to a small extent, raising the possibility that SNMG patients, who have thymic chang
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br Conflict of interest statement br Benign prostatic hyperp
2022-11-17
Conflict of interest statement Benign prostatic hyperplasia (BPH) is a highly complex process characterized by an increased number of epithelial and stromal GSK2879552 in the transition zone. , , Autopsy studies by McNeal detail the evolution of histological changes within these 2 cellular comp
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Introduction Dementia is a common disease in
2022-11-17
Introduction Dementia is a common disease in the elderly, and a significant source of disability, healthcare spending, and long-term care admissions. There is evidence to suggest that testosterone plays a role in cognitive functioning, and lower serum levels correlate with higher amyloid deposits (
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The reductase family is composed of three known
2022-11-17
The 5α-reductase family is composed of three known isozymes, with the types I and II being the most known. Type I isozyme, which is the dominant form, can be found in the skin, liver, kidney, brain and lung. Furthermore, it has been evidenced that type I activity is several times higher in PC than i
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Herbal medicines have been used to treat various
2022-11-17
Herbal medicines have been used to treat various types of diseases and disorders for thousands of years worldwide (Li and Brown, 2009). Natural products have been the remedy of cancer chemotherapy for the past several decades. Anisomeles indica (L.) Kuntze. (Labiatae), commonly known as 'yu-chen-tsa
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br Conclusions A large body
2022-11-17
Conclusions A large body of evidence indicates that oxidative stress is involved in the pathogenesis of NDDs. Hence, reducing oxidative stress or suppressing its downstream pathways may be beneficial for the treatment of these diseases, especially such chronic diseases as AD or glaucoma. Here we
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The Limitations of our data include
2022-11-17
The Limitations of our data include the absence of functional/behavioral assessments and lack of direct comparison with females which would require additional studies and conceivably support sex-specific interventions for stroke [50]. Competing interests Acknowledgements This study was suppor
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br Antioxidant polymers conjugates Natural
2022-11-17
Antioxidant-polymers conjugates Natural antioxidants are usually used as a substitute for synthetics but some degradation phenomena could influence their applications. For example, ascorbic 65 0 as a natural antioxidant undergoes yellowish coloration as a result of oxidation [29]. Sing and Kaplan
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br Declarations Funding None for the
2022-11-17
Declarations Funding: None for the paper in question. Competing interests: Florent Morio has received speaker's fees from Gilead, Basilea, and MSD and travel grants from Gilead, MSD, Pfizer, Basilea, and Astellas. Ethical approval: Not relevant for the paper in question. Introduction Lactic
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Finally terbinafine is generally associated with a low index
2022-11-17
Finally, terbinafine is generally associated with a low index of toxicity and few adverse effects. In humans, only mild GI toxicity and hepatobiliary dysfunction are reported. In red-tailed hawks, oral administration of a high dose of terbinafine (120 mg/kg BW) was furthermore demonstrated to induce
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