• Incubation of the aortic segments of rats with

  2023-10-07

  

  Incubation of the aortic segments of rats with indomethacin significantly decreased the vasoconstrictor response to Phe but only in HgCl2-treated group (Fig. 9A,B), as indicated by dAUC values (Fig. 9E). Co-treatment with losartan once again proved to be effective and prevented the increased partici

• br Experimental procedures br Results

  2023-10-07

  

  Experimental procedures Results Discussion Our biophysical and cellular analyses of mutant Aβ1–42 peptides support a role of the N-terminus of Aβ in peptide aggregation and toxicity. We demonstrate that double mutations constructed to humanize the rodent Aβ1–42 sequence result in a signific

• The beneficial treatment with several statins

  2023-10-03

  

  The beneficial treatment with several statins have been evaluated in AD patients (Kivipelto et al., 2005), with controversial results. It has been suggested that statins slow cognitive decline in mild to moderate AD (Miida et al., 2005). Treatment with atorvastatin, combined with other medications,

• So far many independent studies have

  2023-10-03

  

  So far, many independent studies have linked cholesterol metabolism–related genes with AD, either by showing associations with specific polymorphisms or with differential dpni levels (Beecham et al., 2014, Blain and Poirier, 2004, Lambert et al., 2009, Lambert et al., 2013, Leduc et al., 2015, Papa

• pi3k inhibitors In addition we aimed to examine

  2023-10-03

  

  In addition, we aimed to examine the possible role of adiponectin in modulating changes in IR. It was observed that there was a simultaneous decline in expression of IR and AdipoR1 proteins in the ovary of PCOS-mice as compared to the control ovary. Further, a strong correlation was found between ch

• Sphingolipids such as ceramides and glucosylceramides

  2023-10-03

  

  Sphingolipids, such as ceramides and glucosylceramides, are an important class of bioactive lipids. The levels of these lipids change as a function of adipose tissue mass and functionality, and are partially driven by cellular availability of palmitoyl-CoA. Aberrant accumulation of ceramide, glucos

• In our study caspase and DRAM were identified as

  2023-10-01

  

  In our study, caspase3 and DRAM were identified as being involved in full-length AIFM1-induced apoptosis. Caspase3 is best known for its role in the execution phase of apoptosis in both intrinsic and extrinsic apoptotic pathways [17]. The members of the caspase family are generally in inactive pro-f

• br Funding The present study was funded

  2023-10-01

  

  Funding The present study was funded by The Scientific and Technological Research Council of Turkey (TUBITAK) within Research Program 1001, unique project number: 214S349. Introduction The apelin receptor, also called APJ or angiotensin receptor-like 1 was first cloned in 1993 due to its stro

• In conclusion there are only a

  2023-10-01

  

  In conclusion, there are only a few experimental reports evaluating the influence of sphingosine 1-phosphate receptor modulator on allergy. With the exception of studies using macrolides, most point to their harmful effect on the severity of this disease. Future studies will be crucial to define the

• Recent studies suggest that A caused synapse damage as a

  2023-10-01

  

  Recent studies suggest that Aβ caused synapse damage as a consequence of aberrant cell signalling. As synthetic Aβ42 monomers activate the phosphatidylinositol-3-kinase pathway (Giuffrida et al., 2009) and insulin signalling (Giuffrida et al., 2012) it is possible that Aβ monomers and Aβ oligomers a

• br Therapeutic advantages and clinical

  2023-10-01

  

  Therapeutic advantages and clinical implications of caffeine treatment in ROP The demonstration of the role of the adenosine receptor in development of ROP and protection by caffeine suggests two potential therapeutic strategies with high translational potential: a) modification of caffeine treat

• As an alternative to chronic

  2023-10-01

  

  As an alternative to chronic receptor blockade, we have been targeting adenosine kinase (ADK) – an astrocyte-based enzyme that catalyses the phosphorylation of adenosine, as a means to modify Busulfan adenosinergic signalling (Boison, 2006, Etherington et al., 2009). Up-regulating ADK facilitates t

• Chromatin proteins play important roles

  2023-09-28

  

  Chromatin proteins play important roles in gene expression and DNA repair. The importance of chromatin composition on gene expression is exemplified by X-inactivation, where one of the two X chromosomes in female mammalian S-Adenosylhomocysteine is transcriptionally silenced by heterochromatin , ,

• Introduction Plant pathogenic fungi are major pathogens in a

  2023-09-28

  

  Introduction Plant pathogenic fungi are major pathogens in agricultural diseases and the cause of large crop losses worldwide. There are many kinds of plant pathogenic fungi, with various modes of action. For example, Botrytis cinerea (B. cinerea) is the disease pathogen in the economically importa

• Introduction Cardiovascular disease is the principal cause o

  2023-09-28

  

  Introduction Cardiovascular disease is the principal cause of morbidity and mortality in patients with 5ht receptors (1). Comprehensive management of these patients includes not only adequate glycemic control but also attention to additional recognized risk factors. Hypertension is a cardiovascula

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